Aelianbio.com Website Review

aelian biotechnology combines crispr screening with single-cell sequencing, leveraging two transformative technologies to enable genetic screening for complex phenotypes. we utilize the crispr screening workflow to map the impact of thousands of genetic perturbations on the global transcriptome at single-cell resolution, thus effectively establishing a paradigm for next generation crispr screens. our powerful approach has broad applications in identifying novel drug targets or elucidating unknown mechanisms of actions of. every drug screen starts with a disease model and the suitability of the model has great impact on the success of the screen. hence, it is. critical to functionally validate the disease model and as*ess whether drivers and endpoints of the model appropriately reflect the disease.. aelian’s unique technology supports identification of the critical genes and pathways driving certain disease states or impacting on the.   understanding how drugs act in the complex environment of a cell remains one of the critical aspects of drug discovery and development.. crop-seq delivers transcriptional profiles as*ociated with drug action and indicates which genes affect the drug profile, thus providing. unique insights into drug mechanism of action. it also uncovers genes that modify drug responses, thus paving the way for combination. in recent years, there has been a growing interest in phenotypic drug discovery (pdd) approaches, which uncover drugs based on cellular. read-outs and without prior knowledge of the identity of a specific drug target.  aelian’s unique crop-seq screening platform can help. decipher the molecular target(s) of drug candidates and thus allows pdd projects to move to the next level . crispr screening has revolutionized the unbiased annotation of gene function, but most screens done so far have been confined to rather researchers to as*ess much more complex phenotypes, thus effectively broadening the scope of these screens. at aelian, we use the crispr