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SYSTEMS BIOENGINEERING LABORATORY AZELOGLU LAB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI. The human body is a machine; an electromechanical system that breaks down easily and often. Despite our millennia-long attempt at fixing the human body, our understanding of complex biological systems is rudimentary at best. Systems Bioengineering Lab uses multidisciplinary approaches to understand how the human body operates and malfunctions, and aims to utilize engineering approaches for design of new thera*eutic strategies against complex diseases such as diabetic nephropathy and heart failure. SBL uses novel micro- and nanofabrication techniques, omics technologies, tissue engineering, and cutting-edge computational biology methods to address these How the interaction of physical forces and biochemical processes affects basic cell biology still eludes most scientists. We study systems-level regulation of cell and tissue biomechanics to understand its role in progression of complex diseases, and to discover new drug targets and to design novel thera*eutic strategies based on mechanobiological principles. We combine nanotechnology, functional tissue engineering, and multiple-omics methodologies to study fundamental biological processes Kidney podocytes comprise a specialized actin cytoskeleton with complex dynamic behavior that is key for its physiological function. We seek to understand the mechanisms through which the podocyte actin cytoskeleton affects glomerular function. We are interested in identification and mitigation of adverse effects of targetted cancer thera*eutics. As part of the Systems Biomedicine Institute at Mount Sinai, we investigate the mechanisms of cardiotoxity as*ociated with targeted cancer thera*eutics. For more the renal effects of tyrosine kinase inhiibitors, in particular the altered mechanobiological landscape that may adversely effect actin-as*ociated protein that stabilizes foot process architecture in kidney podocytes” today at the Cellular Crosstalk in Glomerular