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Protein structure is nearly always more conserved than sequence. As a result, when two proteins share a significant sequence similarity, it is extremely likely they will also share similar 3D structure. The following instructions demonstrate how to find significant CATH structural domain matches on your own protein sequence. CATH-Gene3D provides information on the evolutionary relationships of protein domains through sequence, structure and functional annotation The homologous superfamily (H) level of the CATH hierarchical clas*ification groups domains that are related by evolution (find out A relatively small number of CATH superfamilies have developed high levels of sequence, structural and functional diversity The following are considered in the an*lysis of domain evolution: Superfamilies are typically described as being diverse in sequence if they have multiple clusters at a sequence identity of 35%. The measured by looking at the number of structurally-similar groups (or SSGs) that it contains. The Superfamily Superpositions tab on the Superpositions tab on the CATH-Gene3D superfamily web pages demonstrate the concept of an ancient structural core that can seen by FunFams are useful in the prediction of function and in providing information on the evolution of function. Proteins are typically composed of one or more building blocks, called domains. Protein domains are generally considered as Within a superfamily, CATH-Gene3D creates Functional Families (FunFams) that aim to group together domains that share the same function. Therefore, if a region of protein sequence provides a highly significant match to a particular CATH-Gene3D FunFam, then there is a To test this as*ertion, our function prediction pipeline (based on these FunFams) was submitted to the Critical As*essment of protein Function Annotation (CAFA). Our method was ranked highly for accuracy of function prediction according to a number of different scoring The following instructions demonstrate how to find function annotations for your own protein sequence.