Dbaasp.org Website Review

DBAASPV2.13 DATABASE OF ANTIMICROBIAL ACTIVITY AND STRUCTURE OF PEPTIDES. Database of Antimicrobial Activity and Structure of Peptides (DBAASP)  is the manually-curated database. It has been developed to provide the information and an*lytical resources to the  scientific community in order to develop antimicrobial compounds with the high thera*eutic Antimicrobial peptides (AMP) represent  ancient defense  molecules which are widespread in all forms of life, from multi-cellular organisms to  bacterial cell. In many cases, their primary role is in the killing of invading  pathogenic organisms (bacteria, fungi, some parasites and viruses). Recent studies show that some AMPs are active against pathogens that are resistant to conventional antibiotics. Hence, AMPs are widely used in medicine, food preservation and agriculture. and high thera*eutic index requires: full information on structure (chemical, 3D) and activity of natural and artificial peptides for which antimicrobial activity against particular target species have been evaluated experimentally. This means having  information: regarding posttranslational modification (chemical groups bound to the N and C termini of peptide; cycles; modification which take place in particular amino acid) and 3D structure; about antimicrobial and hemolytic(cytotoxic) activities and experimental conditions in which DBAASP provide users with information on detailed structure (chemical, 3D) and activity for those peptides, for which antimicrobial activity against particular target species  have been evaluated experimentally. The database contains information on ribosomal, non-ribosomal and synthetic peptides that show  antimicrobial activity as Monomers, Dimers and Multi-Peptides. Prediction service allows to reveal the existence of antimicrobial activity for the queried peptides based on amino acid sequence information only. The tools providing prediction with the high accuracy allow to conduct task-oriented design of the new antibiotics