Jordandward.com Website Review

​Nestled in the redwoods of the stunning UC Santa Cruz campus, we are interested in how the remarkable complexity and noise of gene regulation is converted into the beautiful and precise cellular behaviors that drive an*mal development. We use genetics, molecular regulate distinct gene expression programs controlling cell division and differentiation and organ development in living an*mals. We focus on transcription factor regulation of two cellular processes: i) the nematode molt, which is the shedding of the old skin (cuticle) causes the disfiguring disease lymphatic filariasis, we aim to understand how gene regulatory networks evolve in the context of a parasitic life cycle. We are motivated by the public health implications of this work: parasitic nematodes infect over 1.5 billion people globally and also threaten food availability by infecting crops and livestock. There are a small number of drugs currently available to fight parasitic nematode infections, so novel approaches are desperately needed. Molting is a good target as it is essential, involves nematode-specific molecules, and is regulated by many druggable targets (proteases, nuclear hormone receptors, etc.). By characterizing key developmental processes in parasites, we aim to develop new approaches to combat helminthic infections.  Powered by Create your own unique website with customizable templates. Get Started