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Fat necrosis is seen where fat concentration is more or lipase concentration is more. Example- Injury to Breast or Omentum tissue or in Acute pancreatitis with gall stones or alcohol intake. Alcohol intake leads to activation of lipase enzyme. This lipase enzyme converts lipids to fatty acids. Always remember fatty acids loves calcium! This love affair leads to formation of FATTY ACIDS - CALCIUM COMPLEX FORMATION. This is called as SAPONIFICATION. This gives yellow - white chalk like color. This helps surgeon to identify fat necrosis. Suppose there is severe pancreatitis. This leads to more activation of the lipase enzyme. This leads to formation of the fatty acids. More fatty acids, more saponification. Hence less calcium level in serum! In normal person, when bacteria is engulfed by WBCs, they are carried to lysosome enzyme by LYST protein. Defect in LYST protein causes Chediak Higashi syndrome. It is AUTOSOMAL RECESSIVE DISORDER. No LYST protein so no phagocytosis of macrophages. Hence recurrent infections. 2) Absence of Melanin - Albinism. LYST also helps in transfer of melanin to superficial layer of skin Confirmation: Incomplete digestion of bacteria leads to formation of  Giant granules inside cell Horner syndrome is a clas*ic neurologic syndrome whose signs include miosis, ptosis, and anhidrosis. NEUROANATOMY - Horner syndrome can result from a lesion anywhere along a three-neuron sympathetic pathway that originates in the ●The first-order neuron descends caudally from the hypothalamus to the first synapse, which is located in the cervical spinal cord ●The second-order neuron travels from the sympathetic trunk over the lung apex. It then ascends to the superior cervical ganglion, located ●The third-order neuron from superior cervical ganglia then ascends within the adventitia of the internal carotid artery, through the cavernous sinus. In the orbit and the eye, the ocu*osympathetic fibers innervate the iris dilator muscle as well as Müller's muscle, a small