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i have the instruments shutdown after the run completes if i’m not there? while sec-mals with a dawn or minidawn is the primary means of characterizing soluble protein aggregates, fff-mals, cg-mals and dls are valuable orthogonal techniques to meet fda requirements. sec or fff plus triple detection uv-mals-ri and astra software determine the molar mas* of protein and modifier in conjugated biothera*eutics such as antibody-drug conjugates or pegylated proteins. microwell plates, detecting aggregation as well as conformational and colloidal stability indicators. cg-mals combines a calypso ii and dawn or minidawn to characterize the affinity and absolute molecular stoichiometry of drug-target binding, without labeling or immobilization. it also an*lyzes self-as*ociation at low, moderate and high concentrations. a dawn or minidawn mals detector, combined with a wyatt sec column and the optilab t-rex dri detector, determine absolute molar mas*es and validate protein purification and stability quickly and easily with a dynapro nanostar cuvette-based, combined dynamic light scattering & static light scattering detector, or a high-throughput dynapro plate reader iii. the möbiuζ is the only electrophoretic light scattering detector capable of providing reliable and repeatable measurements of a cg-mals combines a calypso and dawn or minidawn to characterize the affinity and absolute molecular stoichiometry of simple or complex biomolecular interactions. cg-mals requires no labeling or immobilization, addressing self-as*ociation as well as a dawn mals detector and optilab t-rex dri detector work together to determine distributions of absolute molar mas* and size of natural or light scattering is an excellent means for as*essing the degradation of biopolymers as a result of exposure to heat, light, high or low ph, key ingredients in cosmetics, the paper industry and food products, polysaccharides are also critical materials in biomedical applications such as vaccines and blood coagulants. characterize all types of polysaccharides by sec combined with wyatt's on-line light scattering,